A unified robotic kinematic simulation interface.

Robotic controller and application programming have evolved along with the application of computer technologies. A PC-based, open architecture controller, off-line programming and simulation system integrated in one-box solution presents the latest advancement in robotics. Open architecture controllers have been proven essential for all aspects of reconfiguration in future manufacturing systems. A Unified Reconfigurable Open Control Architecture (UROCA) research project is under way within the Intelligent Manufacturing Systems (IMS) Centre at the University of Windsor. Applications are for industrial robotic, CNC, and automotive control systems. The UROCA proposed architecture is a reconfigurable system that takes the advantages of different control structure types, thereby integrating them in a way to enhance the controller architecture design. This research develops a graphical robotic simulation platform by creating an optimized object-oriented design. (Abstract shortened by UMI.) Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis2005 .D56. Source: Masters Abstracts International, Volume: 44-03, page: 1474. Thesis (M.A.Sc.)--University of Windsor (Canada), 2005

E-business Management System Based on Coordinated Center for Dealer

This management platform has been applied in e-business of the dealer. Based on coordinated center, and it is realized by intranet, extranet and Internet. The structure of the management platform has five parts: information center of management platform, customer relationship management system, purchasing management system, logistics management system and financial management system. With network security, data security, user security and backup etc., the system reliability and security are enhanced. Through Business to Business (B2B) and Business to Customers (B2C), it can help the dealer coordinate with the supplier and the retailer

Proximity effect at superconducting Sn-Bi2Se3 interface

We have investigated the conductance spectra of Sn-Bi2Se3 interface junctions down to 250 mK and in different magnetic fields. A number of conductance anomalies were observed below the superconducting transition temperature of Sn, including a small gap different from that of Sn, and a zero-bias conductance peak growing up at lower temperatures. We discussed the possible origins of the smaller gap and the zero-bias conductance peak. These phenomena support that a proximity-effect-induced chiral superconducting phase is formed at the interface between the superconducting Sn and the strong spin-orbit coupling material Bi2Se3.Comment: 7 pages, 8 figure

Anomalous Cooper pair interference on Bi2Te3 surface

It is believed that the edges of a chiral p-wave superconductor host Majorana modes, relating to a mysterious type of fermions predicted seven decades ago. Much attention has been paid to search for p-wave superconductivity in solid-state systems, including recently those with strong spin-orbit coupling (SOC). However, smoking-gun experiments are still awaited. In this work, we have performed phase-sensitive measurements on particularly designed superconducting quantum interference devices constructing on the surface of topological insulators Bi2Te3, in such a way that a substantial portion of the interference loop is built on the proximity-effect-induced superconducting surface. Two types of Cooper interference patterns have been recognized at low temperatures. One is s-wave like and is contributed by a zero-phase loop inhabited in the bulk of Bi2Te3. The other, being identified to relate to the surface states, is anomalous for that there is a phase shift between the positive and negative bias current directions. The results support that the Cooper pairs on the surface of Bi2Te3 have a 2\pi Berry phase which makes the superconductivity p_x+ip_y-wave-like. Mesoscopic hybrid rings as constructed in this experiment are presumably arbitrary-phase loops good for studying topological quantum phenomena.Comment: supplementary material adde

Second generation androgen receptor antagonist, TQB3720 abrogates prostate cancer growth via AR/GPX4 axis activated ferroptosis

Purpose: Prostate cancer (PCa) poses a great threat to humans. The study aimed to evaluate the potential of TQB3720 in promoting ferroptosis to suppress prostate cancer, providing a theoretical basis for PCa therapy.Methods: PCa cells and nude mice models were divided into TQB3720, enzalutamide (ENZ), and control groups. Sulforhodamine B assay, colony formation assessment, organoids culture system, and the CCK8 assay were used for detecting proliferation. Western blot assay was processed to detect the expression of androgen receptor (AR), ferroptosis, and apoptosis-related genes. Flow cytometry was applied to measure the intracellular ROS levels. ELISA was performed to determine the cellular oxidized glutathione (GSSG) and malondialdehyde (MDA) levels. RT-qPCR was conducted to detect the mRNA expression of genes in AR signaling. BODIPYTM™ 581/591 was processed for detection of intracellular lipid peroxidation levels. The interaction of AR with other translational factor complex proteins was explored using Co-immunoprecipitation (Co-IP), and the chromatin immunoprecipitation (ChIP) assay was performed to detect the binding of AR-involved translational complex to downstream genes promoter. Luciferase reporter assay was conducted to examine the translation activity of GPX4 promoter, and immunohistochemistry (IHC) was conducted to analyze the levels of c-MYC, Ki-67 and AR in TQB3720-treated cancer tissues.Results: Here, we found TQB3720 inhibits the growth of prostate cancer in vitro and in vivo. TQB3720 treatment induced intracellular levels of GSSG and MDA significantly, by which hints AR antagonist caused ferroptosis-related cell death. Moreover, molecular evidence shown TQB3720 regulates downstream of AR signaling by binding AR resulting in inhibition of AR entry into the nucleus. Additional, we also proved that TQB3720 abrogates the interaction between AR and SP1 and leads to decrease GPX4 transcription.Conclusion: TQB3720 promotes ferroptosis in prostate cancer cells by reducing the AR/SP1 transcriptional complex binding to GPX4 promoter. As a result, it is suggested to be a potential drug for clinic prostate cancer treatment

Plasmids from Food Lactic Acid Bacteria: Diversity, Similarity, and New Developments

Plasmids are widely distributed in different sources of lactic acid bacteria (LAB) as self-replicating extrachromosomal genetic materials, and have received considerable attention due to their close relationship with many important functions as well as some industrially relevant characteristics of the LAB species. They are interesting with regard to the development of food-grade cloning vectors. This review summarizes new developments in the area of lactic acid bacteria plasmids and aims to provide up to date information that can be used in related future research